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Symbol Name ID |
Smo
smoothened, frizzled class receptor MGI:108075 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Anorexia |
| Disease(s) Associated with SMO | |
| pancreatic cancer |
| Mouse Phenotypes | nervous system phenotype |
increased cardiac neural crest cell number |
abnormal radial glial cell morphology |
abnormal neuronal migration |
abnormal neuron proliferation |
abnormal neural plate morphology |
increased medulloblastoma incidence |
abnormal enteric neuron morphology |
abnormal brain development |
abnormal cerebellum development |
abnormal cerebellar foliation |
absent cerebellar foliation |
abnormal cerebellum external granule cell layer morphology |
holoprosencephaly |
hydrocephaly |
forebrain hypoplasia |
decreased brain size |
increased brain size |
abnormal diencephalon morphology |
abnormal thalamus morphology |
abnormal lateral geniculate nucleus morphology |
abnormal cerebellum morphology |
ectopic Purkinje cell |
abnormal cerebellar granule cell morphology |
increased cerebellar granule cell number |
small cerebellum |
astrocytosis |
abnormal subarachnoid space morphology |
absent neuronal precursor cells |
increased neuronal precursor cell number |
abnormal spinal cord morphology |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||
| Smobnb/Smobnb | ||||||||||||||||||||||||||||||||
| Smorgsc2073/Smorgsc2073 | ||||||||||||||||||||||||||||||||
| Smotm1.1Pab/Smotm1.1Pab | ||||||||||||||||||||||||||||||||
| Smotm1Amc/Smotm1Amc | ||||||||||||||||||||||||||||||||
| Tg(Neurod2-Smo*A1)199Jols/Tg(Neurod2-Smo*A1)199Jols | * | |||||||||||||||||||||||||||||||
| Tg(Neurod2-Smo*A1)199Jols/0 | ||||||||||||||||||||||||||||||||
| Tg(Neurod2-Smo*A2)#Jols/0 | ||||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc Tg(GFAP-cre)25Mes/0 (conditional) |
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| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc Olig2tm2(TVA,cre)Rth/Olig2+ (conditional) |
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| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc Tlx3tm1(cre)Qima/Tlx3+ (conditional) |
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| Gli1tm3(cre/ERT2)Alj/Gli1+ Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc (conditional) |
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| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc Tg(Atoh1-cre/Esr1*)14Fsh/0 (conditional) |
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| Olig3tm1(cre)Ynka/Olig3+ Smotm2Amc/Smotm2Amc (conditional) |
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| Smotm2Amc/Smotm2Amc Tg(Nes-cre)1Kln/0 (conditional) |
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| Smotm2Amc/Smotm2Amc Tg(Gfap-cre)73.12Mvs/0 (conditional) |
* | |||||||||||||||||||||||||||||||
| Smotm2Amc/Smotm2Amc Slc6a3tm1(cre)Xz/Slc6a3+ (conditional) |
* | |||||||||||||||||||||||||||||||
| Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ (conditional) |
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| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ Olig3tm1(cre)Ynka/Olig3+ (conditional) |
* | |||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ Tg(Nes-cre)1Kln/0 (conditional) |
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| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm7(SMO*/YFP)Amc Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
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| Gt(ROSA)26Sortm7(SMO*/YFP)Amc/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Smotm1Amc/Smotm2Amc Tg(Nes-cre)1Kln/0 (conditional) |
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| Smotm1Amc/Smotm2Amc Tg(Fgf15-cre)1Hisa/0 (conditional) |
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| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/? Tg(CAG-cre/Esr1*)5Amc/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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